“Super-utilizers” have been the subject of much attention as health care systems work to reduce costs and provide better care. As part of their work to understand best practices for addressing the medical and social needs of high-need/high-cost patients, Samantha Iovan, Paula Lantz, Katie Allan, and Mahshid Abir published a systematic review examining interventions that are being implemented to address super-utilizers in prehospital and emergency care settings in the U.S.